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Zinc Profile
By David Tolson

1. What is zinc?

Zinc is an essential trace mineral that plays many roles in the body. It is a component of over 100 enzymes and plays key roles in reproductive function, immune function, and the transport of Vitamin A. Some of the best sources of zinc are crab, beef, turkey, and ham.

2. What application does zinc have?

The utility and need for zinc supplements in athletes is still controversial. It is known that mild zinc deficiency is common in both the general public (6) and athletes specifically (1), but the impact this has on athletic performance is unknown (2). However, there are quite a few reasons to believe that correcting mild zinc deficiency could improve athletic performance, especially in males. First, zinc deficiency is associated with lower testosterone levels (3) and higher estrogen levels (4). Secondly, zinc depletion has negative effects on immune function that can be corrected with supplementation (5). Finally, zinc deficiency may independently lead to lower leptin levels (7). The impact mild zinc deficiency has on the development of insulin resistance in humans has yet to be established.

3. How should I take zinc?

The inorganic forms of zinc found in multivitamins are usually not absorbed very well (8), which is another reason for additional supplementation. Zinc is most bioavailable when it is binded to a ligand/chelator (such as EDTA), amino acid (such as histidine) or organic acid (such as citrate) (6). Zinc methionine is an exception, with studies showing it to have low bioavailability equal to that of the inorganic forms chloride and proprionate, and it is hypothesized that the bond is not strong enough to survive the upper GI tract (6, 9). Zinc picolinate is one of the most bioavailable forms (10), but one of the best ways to increase zinc absorption in any form is to eat it with a large amount of meat or whey protein (casein may inhibit absorption), and this may prevent the inhibitory effect phytates normally have on zinc absorption (6). Although calcium, iron, and copper can all interfere with zinc absorption, studies in human adults confirm that this only happens when the ratio between the two elements is very uneven (6).

The recommendations for daily intake vary between 12-15 mg per day for men or 8-12 mg for women, and the UL (tolerable upper intake) is 40 mg. A low dose zinc supplement should be all that is needed to prevent a deficiency, although up to 30 mg is commonly taken with relative safety. The most important concern with zinc supplementation is the possibility of copper deficiency (11), and if you choose to use high doses of zinc (40 mg+ per day) the general recommendation is an extra 100 mcg of copper for each 10 mg of zinc.

Some of the best zinc supplements are Optimum ZMA and Now Zinc Picolinate (which I recommend taking every other day).

If you have any questions or comments regarding this article, please email dvdtlsn@bulknutrition.com.


No part of this article may be reproduced in any form without the permission of David Tolson or Mike McCandless.

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References
1. Micheletti A, Rossi R, Rufini S. Zinc status in athletes: relation to diet and exercise. Sports Med 2001;31(8):577-82 [abstract]

2. McDonald R, Keen CL. Iron, zinc and magnesium nutrition and athletic performance. Sports Med 1988 Mar;5(3):171-84 [abstract]

3. Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition 1996 May;12(5):344-8 [abstract]

4. Om AS, Chung KW. J Nutr. Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. 1996 Apr;126(4):842-8 [abstract]

5. Ibs KH, Rink L. Zinc-altered immune function. J Nutr. 2003 May;133(5):1452S-6S [abstract]

6. Lonnerdal B. Dietary factors influencing zinc absorption. J Nutr 2000 May;130(5S Suppl):1378S-83S [paper]

7. Ott ES, Shay NF. Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes. Exp Biol Med (Maywood). 2001 Oct;226(9):841-6 [paper]

8. Navarro M, Wood RJ. Plasma changes in micronutrients following a multivitamin and mineral supplement in healthy adults. J Am Coll Nutr 2003 Apr;22(2):124-32 [abstract]

9. Beutler KT, Pankewycz O, Brautigan DL. Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. Biol Trace Elem Res 1998 Jan;61(1):19-31 [abstract]

10. Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC. Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents Actions. 1987 Jun;21(1-2):223-8 [abstract]

11. Abdallah SM, Samman S. The effect of increasing dietary zinc on the activity of superoxide dismutase and zinc concentration in erythrocytes of healthy female subjects. Eur J Clin Nutr 1993 May;47(5):327-32 [abstract]

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